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Siegel Lab - Molecular Parasitology

Physiological Chemistry and Experimental Parasitology

siegelResearch Topics

  • Chromatin organization
  • Genome architecture
  • Antigenic variation
  • Trypanosoma brucei


Prof. Dr. Nicolai Siegel

phone: +49 (0)89 - 2180 77098

Photo: Jan Greune

We are interested in how pathogens benefit from cell-to-cell heterogeneity and in the mechanisms controlling heterogeneity in a population. Our research relies on different single cell technologies and many high throughput sequencing-based approaches to study the transcriptome, chromatin organization and genome architecture in unicellular eukaryotes. One key question of our research is how pathogens regulate antigenic variation at the genomic and transcriptional level. As a model we use the protozoan parasite Trypanosoma brucei, the causative agent of African sleeping sickness. Read more...


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Scientific vita

since 2017 Professor Faculty of Veterinary Medicine, Experimental Parasitology
Dept. Physiol. Chemistry, Biomedical Center Munich, LMU Munich
2012-2017 ZINF Young Investigator Institute for Molecular Infection Biology, University of Würzburg
2010-2011 EMBO / HFSP Postdoctoral Fellow Scherf Lab, France Dept. of Parasitology & Mycology, Institut Pasteur, Paris, France
2009 PhD The Rockefeller University, New York, USA, Advisor: George Cross