Our department investigates the nuclear and cellular processes that allow organisms to rapidly react and adapt to environmental changes. We identify and analyze novel molecular mechanisms that dynamically regulate the maintenance and adaptation of chromatin structure and gene transcription, focusing in particular on the role of nutrients, metabolites, DNA damage, signaling networks and mitochondrial function. How does metabolism regulate gene activity? How do stresses such as DNA damage and animal learning condition chromatin plasticity, gene activity, mitochondrial function and animal behaviour? We exploit powerful model systems such as multiple yeast species, the fruit fly Drosophila and cultured mammalian cells. The working environment at the Physiologial Chemistry is highly collaborative, interdisciplinary and international, and we utilize methods that range from the resolution of atoms (structural biology, biophysics, biochemistry) to cell biology (live-cell imaging), functional genomics and in vivo approaches. In addition to PhDs and postdocs, we welcome school children, summer students and sabbatical visitors.
Großhaderner Strasse 9
+49 (0)89 2180 77095