Biomedical Center Munich

Language Selection

Breadcrumb Navigation


Korber Lab - Nucleosome positioning and remodeling in yeasts

Molecular Biology

korberResearch Topics

  • Nucleosome positioning
  • Genome-wide in vitro chromatin reconstitution
  • S. cerevisiae, S. pombe
  • ATP-dependent chromatin remodeling


PD Dr. Philipp Korber

phone: +49 (0)89 - 2180 75435

Photo: Jan Greune

Nuclear DNA is organized into nucleosomes, often with defined positions along the DNA. Nucleosome positioning regulates DNA accessibility and thereby fundamentally regulates all genomic processes. We study nucleosome positioning mechanisms with unicellular yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe as in vivo and in vitro model. As our specialty, we established the first genome-wide reconstitution system that allows the biochemical characterization of factors and their roles in nucleosome positioning. We find that ATP-dependent chromatin remodelers are key nucleosome positioning determinants. Read more...


ORCID logo

Scientific vita

since 2006 Group leader Dept. Molecular Biology, Biomedical Center, LMU Munich
2000-2005 Postdoctoral researcher Wolfram Hörz Lab, Division of Molecular Biology, Adolf-Butenandt-Institute, LMU Munich
2000 PhD University of Regensburg, advisor: R. Jaenicke, external advisor: J.C.A. Bardwell (University of Michigan)