Korber Lab - Nucleosome positioning and remodeling in yeasts
Molecular Biology
Research Topics
- Nucleosome positioning
- Genome-wide in vitro chromatin reconstitution
- S. cerevisiae, S. pombe
- ATP-dependent chromatin remodeling
Photo: Jan Greune
Nuclear DNA is organized into nucleosomes, often with defined positions along the DNA. Nucleosome positioning regulates DNA accessibility and thereby fundamentally regulates all genomic processes. We study nucleosome positioning mechanisms with unicellular yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe as in vivo and in vitro model. As our specialty, we established the first genome-wide reconstitution system that allows the biochemical characterization of factors and their roles in nucleosome positioning. We find that ATP-dependent chromatin remodelers are key nucleosome positioning determinants. Read more...
Publications
https://orcid.org/0000-0001-7526-6549
Scientific vita
| Year | Function | Institute |
|---|---|---|
| since 2006 | Group leader | Dept. Molecular Biology, Biomedical Center, LMU Munich |
| 2000-2005 | Postdoctoral researcher | Wolfram Hörz Lab, Division of Molecular Biology, Adolf-Butenandt-Institute, LMU Munich |
| 2000 | PhD | University of Regensburg, advisor: R. Jaenicke, external advisor: J.C.A. Bardwell (University of Michigan) |