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Götz Lab - Neurogenesis

Physiological Genomics

goetzResearch Topics

  • Neural stem cells
  • Neurogenesis
  • Glia-to-neuron reprogramming
  • Neuronal repair

Photo: Jan Greune

We study the mechanisms of brain development and neurogenesis to understand basic novel mechanisms of neural stem cell self-renewal and differentiation and mechanisms of neuronal fate specification which we can then transfer aiming towards repair. Neurons are not replaced after injury or in neurodegenerative disease. We have therefore pioneered the approach to turn local glial cells in the adult mammalian brain into new neurons and now work on improving this conversion, examining the integration of the new neurons and targeting scar-forming glia for reprogramming to also alleviate scar-formation. Read more...


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Scientific vita

since 2011 W3 Professorship Dept. Physiological Genomics, Biomedical Center, LMU Munich
since 2004 Chair of Physiological Genomics Medical Faculty, LMU Munich
since 2004 Director Stem Cell Institute, GSF – since 01.01.2008: Helmholtz Zentrum München, Neuherberg-Munich
1997-2003 Group Leader Max-Planck Institute of Neurobiology, Martinsried
1997 Scientist Max-Planck Institute of Biophysical Chemistry, Göttingen
1994-1996 Postdoctoral Scientist SmithKline Beecham Harlow, U.K
1993-1994 Postdoctoral Fellow National Institute for Medical Research, London, U.K.
1992 PhD in Biology Friedrich-Miescher Institute of the Max-Planck Society, Tübingen