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Steiner Lab - Biochemistry of γ-Secretase


steinerResearch Topics

  • Recognition and processing of γ-secretase substrates
  • Modulation of γ-secretase actvity
  • Lipid dependence of γ-secretase activity



Prof. Dr. Harald Steiner

phone: +49 (0)89 - 4400 46535

Photo: Jan Greune

Our lab studies the function and mechanism of γ-secretase, a pivotal intramembrane protease complex critically involved in the generation of neurotoxic Alzheimer´s disease-associated amyloid-β peptides (Aβ), nuclear signaling and membrane proteostasis. We use state of the art biochemical, molecular biology and cell biological methods to get insight into how this fascinating proteolytic enzyme works.  Read more...


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Scientific vita

since 2007 Professor Dept. Metabolic Biochemistry, Biomedical Center, LMU Munich
1999-2007 Senior scientist and Group leader Adolf-Butenandt-Institute, LMU Munich
1996-1999 Postdoctoral researcher Christian Haass Lab, Central Institute of Mental Health, Mannheim (University of Heidelberg)
1996 PhD in Biochemistry LMU Munich, Advisor: Walter Neupert