Rupp Lab - Developmental Epigenetics
Molecular Biology
Research Topics
- Chromatin-based regulation of vertebrate development
- Histone modification profiling and mass spectrometry
- Cell cycle and embryonic differentiation
- Developmental programs and gene regulatory networks
We study chromatin-based mechanisms which guide developmental transitions in Xenopus embryos. Currently, we focus on molecular mechanisms which establish the histone modification landscape during vertebrate embryogenesis. We hold special expertise in identifying signaling pathways and transcriptional programs which underlie embryonic phenotypes brought about by perturbing chromatin modifying enzymes. The techniques we apply include classical embryonic experimentation, various gain- and loss-of-function analyses, confocal microscopy and state-of-the-art genome-wide approaches (RNA-/ChIP-Seq, Mass Spectrometry). Read more...
Publications
https://orcid.org/0000-0002-8068-9957
Scientific vita
| Year | Function | Institute |
|---|---|---|
| since 2000 | Associate professor | Dept. Molecular Biology, Biomedical Center, LMU Munich |
| 1993-2000 | Independent group leader | Friedrich Miescher Laboratory, MPG Tübingen |
| 1990-1993 | Postdoctoral researcher | Fred Hutchinson Cancer Research Center, Seattle, WA, USA |
| 1989 | PhD in Biology | University of Heidelberg |