Ladurner Lab - Molecular regulation of chromatin plasticity
Physiological Chemistry
Research Topics
- Molecular dissection of PARP signalling
- Dissection of chromatin plasticity in disease
- Metabolic regulation of gene activity
- Genome-maintenance roles of histone chaperones
Photo: Jan Greune
We are interested in identifying, characterizing and exploiting novel molecular mechanisms that underlie the level of regulatory plasticity in chromatin structure. We are uncovering some of the fundamental mechanisms that govern the function of our complex genome and its ability to adapt to new environments. A focus of our group lies in the role of post-translational modifications (in particular, acetylation and ADP-ribosylation signalling ) and of cellular metabolites in regulating the assembly and remodelling of chromatin and gene transcription, for example through the regulation of ATP-dependent chromatin remodellers. Read more...
Publications
https://orcid.org/0000-0003-3835-232X
Scientific vita
| Year | Function | Institute |
|---|---|---|
| since 2019 | Founder and CSO | Eisbach Bio GmbH, Martinsried |
| since 2010 | Full professor and Chair | Dept. Physiol. Chemistry, Biomedical Center, LMU Munich |
| 2003-2011 | Group leader | Genome Biology Unit, EMBL, Heidelberg |
| 2002-2003 | Editor, Nature Structural & Molecular Biology | Nature Publishing Group, New York, USA |
| 1998-2002 | Postdoctoral Associate | Tijan Lab, HHMI, UC Berkeley, USA |
| 2000 | PhD in Chemistry | University of Cambridge, U.K., Advisor: Sir Alan Fersht |