Burbulla Lab - Translational Disease Modeling
Biochemistry
Research Topics
- Neurodegeneration
- Parkinson's disease and Neurodegeneration with Brain Iron Accumulation (NBIA) disorders
- Induced pluripotent stem cells (iPSC), dopaminergic neurons, astrocytes and microglia
- Dopamine metabolism and oxidative stress
Prof. Dr. Lena Burbulla
phone: +49 (0)89 - 4400 46493
lena.burbulla@med.uni-muenchen.de
Photo: Jan Greune
The Burbulla lab aims to investigate underlying mechanisms of dopaminergic neuron degeneration in Parkinson’s disease and related disorders. We are interested in understanding the complexity of dopamine metabolism in pathology, specifically interactions between dopamine, iron and (mitochondrial) oxidant stress. Our work combines a portfolio of diverse techniques including iPSC culture, subsequent differentiation into disease-relevant cell types (midbrain dopaminergic neurons, astrocytes, microglia), biochemical and cellular assays, integrated multi-omics analyses, and HPLC-ECD. Our ultimate goal is to unravel novel targets for therapeutic intervention. Read more...
Publications
Scientific vita
| Year | Function | Institute |
|---|---|---|
| since 2021 | Associate Professor (since 02/2022 Heisenberg Professor) | Dept. Metabolic Biochemistry, Biomedical Center, LMU Munich |
| since 2021 | Adjunct Assistant Professor | Feinberg School of Medicine, Northwestern University, Chicago, USA |
| 2018-2021 | Research Assistant Professor | Feinberg School of Medicine, Northwestern University, Chicago, USA |
| 2013-2018 | Postdoctoral researcher | Feinberg School of Medicine, Northwestern University, Chicago, USA |
| 2012-2013 | Postdoctoral researcher | MGH, Harvard Medical School, Boston, USA (lab relocated to Chicago) |
| 2012 | PhD in Biology | Hertie Institute for Clinical Brain Research, University of Tübingen |