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Burbulla Lab - Translational Disease Modeling

Biochemistry

burbullaResearch Topics

  • Neurodegeneration
  • Parkinson's disease and Neurodegeneration with Brain Iron Accumulation (NBIA) disorders
  • Induced pluripotent stem cells (iPSC), dopaminergic neurons, astrocytes and microglia
  • Dopamine metabolism and oxidative stress

Prof. Dr. Lena Burbulla

phone: +49 (0)89 - 4400 46493
lena.burbulla@med.uni-muenchen.de

Photo: DZNE/Frommann

The Burbulla lab aims to investigate underlying mechanisms of dopaminergic neuron degeneration in Parkinson’s disease and related disorders. We are interested in understanding the complexity of dopamine metabolism in pathology, specifically interactions between dopamine, iron and (mitochondrial) oxidant stress. Our work combines a portfolio of diverse techniques including iPSC culture, subsequent differentiation into disease-relevant cell types (midbrain dopaminergic neurons, astrocytes, microglia), biochemical and cellular assays, integrated multi-omics analyses, and HPLC-ECD. Our ultimate goal is to unravel novel targets for therapeutic intervention. Read more...

Publications

https://www.ncbi.nlm.nih.gov

Scientific vita

YearFunctionInstitute
since 2021 Associate Professor (since 02/2022 Heisenberg Professor) Dept. Metabolic Biochemistry, Biomedical Center, LMU Munich
since 2021 Adjunct Assistant Professor Feinberg School of Medicine, Northwestern University, Chicago, USA
2018-2021 Research Assistant Professor Feinberg School of Medicine, Northwestern University, Chicago, USA
2013-2018 Postdoctoral researcher Feinberg School of Medicine, Northwestern University, Chicago, USA
2012-2013 Postdoctoral researcher MGH, Harvard Medical School, Boston, USA (lab relocated to Chicago)
2012 PhD in Biology Hertie Institute for Clinical Brain Research, University of Tübingen